多酚 ›› 2021, Vol. 3 ›› Issue (1): 1-13.

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A review: effect and mechanism of plant extracts rich in polyphenols on reducing uric acid activity

  

  • 出版日期:2021-12-03 发布日期:2021-12-02

A review: effect and mechanism of plant extracts rich in polyphenols on reducing uric acid activity

  • Online:2021-12-03 Published:2021-12-02

摘要: Abstract Hyperuricemia is a metabolic condition caused by the increase of uric acid level in the body, which can lead to gout, kidney disease, cardiovascular disease, hypertension and diabetes. In recent years, the incidence rate of hyperuricemia has been increasing and gradually becoming younger. Allopurinol and febuxostat are commonly used drugs to reduce the level of uric acid in the body. Although these drugs have good curative eff ect, they can produce adverse reactions. Therefore, it has been the focus of attention to fi nd appropriate treatment and new drugs to reduce serum uric acid level. Natural plants have become the source of new drugs for their multiple biological activities, strong effi cacy and minimal side eff ects. More and more studies have shown that natural plant extracts rich in phenols, fl avonoids and other active components can signifi cantly reduce the level of uric acid, and improve the complications caused by high uric acid. In this paper, hyperuricemia related diseases, functional plants rich in polyphenols with the effect of reducing uric acid and the mechanism of their active components were reviewed.

关键词: hyperuricemia, uric acid, xanthine oxidase, plant extracts, polyphenols

Abstract: Abstract Hyperuricemia is a metabolic condition caused by the increase of uric acid level in the body, which can lead to gout, kidney disease, cardiovascular disease, hypertension and diabetes. In recent years, the incidence rate of hyperuricemia has been increasing and gradually becoming younger. Allopurinol and febuxostat are commonly used drugs to reduce the level of uric acid in the body. Although these drugs have good curative eff ect, they can produce adverse reactions. Therefore, it has been the focus of attention to fi nd appropriate treatment and new drugs to reduce serum uric acid level. Natural plants have become the source of new drugs for their multiple biological activities, strong effi cacy and minimal side eff ects. More and more studies have shown that natural plant extracts rich in phenols, fl avonoids and other active components can signifi cantly reduce the level of uric acid, and improve the complications caused by high uric acid. In this paper, hyperuricemia related diseases, functional plants rich in polyphenols with the effect of reducing uric acid and the mechanism of their active components were reviewed.

Key words: hyperuricemia, uric acid, xanthine oxidase, plant extracts, polyphenols