摘要：
Non-alcoholic fatty liver disease (NAFLD), a chronic liver disorder closely associated with metabolic
dysfunction, has become a significant global health challenge. In recent years, procyanidin B1 (PB1) has demonstrated
potential advantages in the prevention and personalized treatment of NAFLD through multi-target and multi-pathway
intervention strategies, exerting comprehensive regulatory and synergistic effects. However, its precise therapeutic
mechanisms remain unclear. This study employs network pharmacology to identify key targets and potential pathways
involved in the treatment of NAFLD with PB1. Additionally, molecular docking analysis is conducted to validate the
reliability of these targets. The findings provide a theoretical foundation for the development of PB1 as a potential
therapeutic agent for NAFLD, offering insights for future experimental and clinical research.
Jianing Su, Jie Sun, Hongyue Wang, Jiaqing Cao , Xiangrong Zhang .
The mechanism of procyanidin B1 in the treatment of nonalcoholic fatty
liver disease based on network pharmacology and molecular docking
[J]. 多酚, 2025, 7(2): 79-90.
Jianing Su, Jie Sun, Hongyue Wang, Jiaqing Cao , Xiangrong Zhang .
The mechanism of procyanidin B1 in the treatment of nonalcoholic fatty liver disease based on network pharmacology and molecular docking
[J]. Journal of Polyphenols, 2025, 7(2): 79-90.
