Efficient semisynthetic approach for large preparation of procyanidin C1 through degradation of grape seed polymeric procyanidins

Journal of Polyphenols ›› 2022, Vol. 4 ›› Issue (1): 32-41.

Efficient semisynthetic approach for large preparation of procyanidin C1 through degradation of grape seed polymeric procyanidins

Online:2022-09-26 Published:2022-09-26

Abstract

Abstract: Abstract An efficient method for producing trimeric procyanidin C1 (PCC1) was developed through degradation of grape seed polymeric procyanidins (PPCs), using epicatechin (EC) as nucleophile and hydrochloric acid as catalyst. With the yield of PCC1 as the evaluation index, the degradation conditions were optimized by Box-Behnken Design (BBD) based on the results of single-factor experiments. The results showed that the optimal conditions were reaction temperature of 40 ℃, the ratio of EC and PPCs 2:1, acidity of 0.10 mol/L, and reaction time of 20 min. The yield of PCC1 reached up to 17.7 mg by only one-step degradation of 3 g PPCs. This work proposed a new method for large preparation of PCC1 from waste grape seed polymeric procyanidins.

Key words: procyanidins, epicatechin, degradation, grape seed

Qian Li, Lina Zhang, Danyang Wang, Mengyao Zhao, Baoshan Sun, Shuting Zhang. Efficient semisynthetic approach for large preparation of procyanidin C1 through degradation of grape seed polymeric procyanidins[J]. Journal of Polyphenols, 2022, 4(1): 32-41.

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