Journal Of
Polyphenols

Abstract: Abstract Kaempferol (KA), as one of the fl avonoids, has extensive pharmacological properties. However, the poor solubility of KA severely limits its clinical application. In our study, the kaempferol phospholipid complex (KA-PC) has been prepared by solvent evaporation for the enhancement of the bioavailability of KA. KA-PC was verifi ed by scanning electron microscope characterization methods. Drug loading, solubility and long-term stability were measured. The characterization results showed that KA-PC was formed through the intermolecular interaction between KA and phospholipids. The solubility of KA-PC in water was 189 times higher than that of KA, and the solubility in n-octanol was also signifi cantly improved. Besides, pharmacodynamic studies showed that KA-PC can signifi cantly reduce the level of serum uric acid in mice without causing renal injury. This study expanded the clinical application of KA by preparing KA-PC.