Journal Of
Polyphenols

Abstract: Abstract Paeonol is a bioactive phenol present in Dioscorea japonica, Paeonia suffruticosa and Paeonia lactiflora. It is the main active ingredient in the traditional Chinese medicines Mudanpi and Xu Changqing. Clinical applications of paeonol are mainly focused on anti-inflammatory effects due to its ability to act as an antioxidant, a regulator of inflammatory enzyme activities, a modulator of inflammatory signaling pathways and a regulator of adhesion molecules to modulate inflammation through molecular mechanisms of action. In addition, paeonol also regulates infl ammation by regulating the metabolism of gut microbes. In this review, we searched PubMed, Web of Science, ESI and other websites using “paeonol” “infl ammation” “oxidative stress” “signaling pathways” and “gut microbiota” as keywords. We mainly referred to the relevant literature in the last decade and systematically summarized the studies on the anti-inflammatory effects of paeonol to provide a reference for new drug development and clinical application of paeonol.

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