Journal Of
Polyphenols

Abstract: Evidence of the advantages of Solanum nigrum L. for the treatment of ulcerative colitis is accumulating. However, research revealing the treatment of Solanum diphyllum L. against ulcerative colitis is scarce. In this study, the chemical components of the extract of Solanum diphyllum L. were characterized by LC-MS/MS, identifying 31 compounds by positive and negative total ion flow maps. A total of 425 component target genes and 1 900 disease target genes were obtained, and 121 intersection targets and 6 core targets were obtained after the intersection of the two genes by means of network pharmacology. GO analysis and KEGG analysis respectively obtained 20 signaling pathways such as anti-infl ammation. The results of molecular docking showed that the chemical components could successfully dock with the target proteins of the disease such as SRC, EGFR, PTGS2, MMP9, HSP90AA1, ESR1. This study provided a scientific basis for the development and application of Solanum diphyllum L.

Key words: LC-MS/MS, ulcerative colitis; Solanum diphyllum L., network pharmacology, molecular docking