Journal Of
Polyphenols

The aim of this study was to enhance the applicability of genistein (GEN) and investigate genistein solid  dispersion (GEN-SD). The optimal process parameters were determined as follows: anhydrous ethanol volume ratio of 4:1,  ultrasonication time of 30 min, rotary evaporation temperature of 50 °C, and a drug-to-carrier mass ratio of 1:7. The results  of the dissolution and solubility experiments showed that the dissolution rate and solubility of the optimized solid dispersion  were signifi cantly improved compared to pure GEN. Comprehensive characterization of the GEN-SD using X-ray diff raction,  differential scanning calorimetry, scanning electron microscopy, and Fourier transform infrared spectroscopy clarified  variations in crystalline form, thermal properties, and microscopic morphology. Antioxidant experiments showed that GENSD exhibited antioxidant activity and could effectively scavenge various free radicals. Stability studies demonstrated that  GEN-SD was stable at a high temperature of 60 ℃ and a light intensity of 4500 lx.