多酚杂志

本期目录

2025年, 第7卷, 第2期　刊出日期：2025-06-20 上一期   

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Antioxidant mechanisms and applications of apple polyphenol s in food: A review Qiuxin Lu † , Xiaoya Pan † , Liangjun Wu, Caihong Shi , Xiangrong Zhang 2025 (2):  47-58.  摘要 ( 10 )   PDF(4118KB) ( 7 )   Apple polyphenols are widely present in apple pulp, peel, kernel, and leaves. They are natural bioactive substances with a variety of health functions. This review describes the antioxidant functions of anthocyanins, quercetin, phlorizin, chlorogenic acid, and epicatechin in apple polyphenols through the regulation of signal pathways and transcription factors, and the inhibition or induction of enzymes. Massive food applications of apple polyphenols are summarized, including excellent color protection of fruits and vegetables, meat preservation, preparation of composite packaging films as active ingredients, enhancement of nutritional value as functional ingredients, and improvement of food taste and physical stability. This review would provide a reference for the exploration of apple polyphenol resources and its development in the food field. 相关文章 | 计量指标

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Exploring the mechanism of Crataegus pinnatifida fruit flavonoids to improve Alzheimer’s disease based on network pharmacology and molecular docking Dehong Zhang, Xuqian Niu, Rongzheng Deng, Anna Gan, Fei Lin, Jinyu Wang, Bo Wu, Tingxu Yan , Ying Jia 2025 (2):  59-69.  摘要 ( 17 )   PDF(4599KB) ( 20 )   This study aims to explore the mechanism by which flavonoids in Crataegus pinnatifida fruit improve Alzheimer’s disease (AD) through network pharmacology and molecular docking technology. The flavonoid components present in Crataegus pinnatifida fruit were gathered from the HERB, HIT, and ETCM databases, and were further supplemented by relevant published literature. The PubChem and SwissTargetPrediction databases were utilized to predict potential targets, and a “Crataegus pinnatifida fruit-active ingredient-target” network was constructed using Cytoscape 3.9.0 software. The GeneCards database was utilized to identify targets associated with AD, which were subsequently intersected with the active targets of Crataegus pinnatifida fruit. A protein-protein interaction (PPI) network was constructed using the STRING platform. KEGG enrichment analysis of the core targets was conducted on an online bioinformatics mapping platform, while molecular docking of the primary active components and core targets was executed using AutoDock software. Eight flavonoids and 160 potential targets were identifi ed from Crataegus pinnatifida fruit, of which 147 targets were linked to AD. The results of the “Crataegus pinnatifida fruit-active ingredient-target” network indicated that quercetin was the principal flavonoid active ingredient. PPI analysis revealed that SRC and EGFR were the key targets, and KEGG analysis identified the main enrichment pathways as Pathways in cancer, PI3K/Akt signaling pathway, and Proteoglycans in cancer. Molecular docking confirmed the strong binding affinity between the core targets and the primary active ingredient. The interaction of quercetin with the key targets SRC and EGFR may represent a significant mechanism by which flavonoids from Crataegus pinnatifida fruit contribute to the improvement of AD. 相关文章 | 计量指标

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The impact of climate change on polyphenols in mountain grapes (Vitis amurensis Rupr.) in Northeast China: A mini review Xiaoxiao Xu, Wei Zheng , Xu Zhao 2025 (2):  70-78.  摘要 ( 11 )   PDF(844KB) ( 16 )   Climate change is significantly altering viticultural practices worldwide, with profound implications for the accumulation of polyphenolic compounds that determine wine’s sensory and health properties. This review summarizes the effects of climate change, particularly rising temperatures, shifting precipitation patterns, and altered light conditions— on polyphenol synthesis in Vitis amurensis (V. amurensis) grapes from Northeast China, the country’s highest-latitude wine region. Key findings reveal that: (1) Temperature increases accelerate phenological stages but differentially impact polyphenols, suppressing anthocyanins and flavonols while promoting tannins; (2) Precipitation variability induces water stress that can enhance anthocyanin content under moderate drought but reduce quality during extreme events; (3) Declining sunshine duration may limit polyphenol production, though certain cultivars (e.g., Beibinghong) exhibit adaptability to low light conditions. The region’s unique climatic trends — stronger winter warming and reduced summer precipitation— paradoxically offer potential benefits by extending the growing season while minimizing heat stress during critical ripening periods. It is highlighted how V. amurensis, with its cold hardiness and naturally high polyphenol content (notably anthocyanins and resveratrol), could become increasingly valuable under climate change. However, strategic adaptation through cultivar selection, vineyard management, and stress-responsive breeding will be critical to maintain wine quality. This synthesis provides a framework for understanding climate-polyphenol dynamics in cool-climate viticulture and outlines research priorities to safeguard the future of Northeast China’s distinctive wine industry. 相关文章 | 计量指标

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The mechanism of procyanidin B1 in the treatment of nonalcoholic fatty liver disease based on network pharmacology and molecular docking Jianing Su, Jie Sun, Hongyue Wang, Jiaqing Cao , Xiangrong Zhang 2025 (2):  79-90.  摘要 ( 14 )   PDF(3325KB) ( 12 )   Non-alcoholic fatty liver disease (NAFLD), a chronic liver disorder closely associated with metabolic dysfunction, has become a significant global health challenge. In recent years, procyanidin B1 (PB1) has demonstrated potential advantages in the prevention and personalized treatment of NAFLD through multi-target and multi-pathway intervention strategies, exerting comprehensive regulatory and synergistic effects. However, its precise therapeutic mechanisms remain unclear. This study employs network pharmacology to identify key targets and potential pathways involved in the treatment of NAFLD with PB1. Additionally, molecular docking analysis is conducted to validate the reliability of these targets. The findings provide a theoretical foundation for the development of PB1 as a potential therapeutic agent for NAFLD, offering insights for future experimental and clinical research. 相关文章 | 计量指标