多酚杂志

本期目录

2025年, 第7卷, 第1期　刊出日期：2025-03-20 上一期   

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Simulated digestive behavior of naringin microspheres and its influence on yogurt: The rheology and antioxidant activities Hongyue Wang, Tong Zhang, Shuhan Liu, Xiangrong Zhang, Baoshan Sun 2025 (1):  1-7.  摘要 ( 7 )   PDF(3182KB) ( 14 )   Abstract In this study, naringin was encapsulated in microspheres and its simulated digestive behavior in vitro was examined. Then naringin microspheres was added in yogurt to investigate the rheology and antioxidant activities. The results indicated that encapsulating naringin in microspheres delayed its digestion in the stomach, allowing more release in the intestinal part. All kinds of yogurt were solid-like in nature and the addition of microspheres increased the elastic modulus and viscosity. The naringin and microspheres incorporation enhanced the total phenolic content of the yogurt to 6.7 and 8.8 mg of gallic acid equivalent/mL, respectively. All kinds of yogurt demonstrated more than 80% scavenging ability for hydroxyl radicals at 20 μL whey/mL. The addition of microspheres improved the DPPH radical scavenging ability of yogurt. This study provides a new idea for the application of polyphenols in food and the development of functional yogurt. 相关文章 | 计量指标

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Exploring the mechanism of sea buckthorn polyphenols for the treatment of hyperlipidemia based on network pharmacology and molecular docking Yizhuo Geng, Lei Zhou, Haimiao Chen, Youdong Zhao, Tingxu Yan, Ying Jia 2025 (1):  8-19.  摘要 ( 10 )   PDF(5239KB) ( 16 )   Abstract The aim of this study was to explore the mechanism of action of sea buckthorn polyphenols in the treatment of hyperlipidemia through network pharmacology and molecular docking. The TCMSP pharmacology database was used to screen the polyphenols present in sea buckthorn, and then the SwissTargetPrediction and Uniprot databases were used to obtain the potential targets of sea buckthorn polyphenols, which were supplemented by the literature. In total, 7 polyphenols and 154 potential targets were obtained. Through GeneCards, OMIM database, 1 358 hyperlipidemia-related targets were collected. We found that there were 101 targets at the intersection of components and diseases. Through GO and KEGG enrichment analysis, 27 core targets were obtained, which were AKT1, TNF, TP53, IL-6, etc. in order of degree value. 174 pathways were obtained from KEGG enrichment analysis, including AGE-RAGE signaling pathway in diabetic complications, fluid shear stress and atherosclerosis, lipid and atherosclerosis, etc. The molecular docking of the main components to the targets was performed using OpenBabelGUI, AutoDockTools-1.5.6 software. Finally, the results were visualized using Cytoscape 3.9.1 software. The molecular docking results showed that sea buckthorn polyphenols have good binding ability with the key targets. Among them, such as quercetin and kaempferol, have good binding ability with TNF, TP53 and IL-6. For example, TNF binds to quercetin with a binding energy of -5.34 kcal/mol and to kaempferol with a binding energy of -6.22 kcal/mol; TP53 binds to kaempferol with a binding energy of -5.32 kcal/mol; IL-6 binds to quercetin with a binding energy of -5.62 kcal/mol, etc. Therefore, the network pharmacology study showed that the treatment of hyperlipidemia by sea buckthorn polyphenols can be realized by multi-component-multi-target-multi-pathway together, which provides some reference for the later study of sea buckthorn polyphenols in the treatment of hyperlipidemia. 相关文章 | 计量指标

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Network pharmacology and molecular docking based study on the potential mechanism of the treatment of colitis by Solanum nigrum Linn. Bingxin Zhang, Zhennan Meng, Kexin Huang, Ziqi Sun, Xiaoshu Zhang 2025 (1):  20-31.  摘要 ( 9 )   PDF(3479KB) ( 7 )   Abstract The purpose of this study was to characterize the chemical components of the extract of Solanum Nigrum Linn. (SNL), by LC-MS/MS, and to identify 33 compounds by positive and negative total ion flow maps. Network pharmacology and molecular docking methods were used to investigate the mechanism of action of SNL against ulcerative colitis (UC). A total of 282 component target genes and 1 850 disease target genes were obtained, and 157 cross-targets and 16 core-targets were obtained after crossover. A total of 20 signaling pathways such as anti-inflammatory and anti-apoptotic were obtained by GO analysis and KEGG analysis, respectively. It is possible that the anti UC effect can be achieved by regulating proteins such as AKT1, EGFR, NFKB1, JUN, and HSP90AA1. Molecular docking results show that the anti UC active ingredients are well docked with the target protein molecules This study provides a scientific basis for the development and utilization of SNL. 相关文章 | 计量指标

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A review on the function and application of polyphenol compound of quinoa Jianle Si, Keshuang Guo, Xin Li, Yingtong Ma, Jianxin Song, Xiangrong Zhang 2025 (1):  32-43.  摘要 ( 11 )   PDF(6203KB) ( 14 )   Abstract Quinoa is pseudo cereal and considered as full nutritional food for its functional ingredients such as peptides, polysaccharides, saponins and polyphenols. Up to now, over 20 phenolic compounds have been reported in quinoa, and these polyphenols are related to anti-cancer, anti-inflammatory, anti-obesity, anti-diabetic and cardioprotective activities. Recently, more and more attentions are focused on quinoa in the food and pharmaceutical fields. Many new products such as bakery, beverage and meat product made from quinoa are popular in the market. This article presents a review of the literature on the function and application of polyphenols in quinoa. The review will benefit the researchers working with nutrition, functional diets of quinoa. 相关文章 | 计量指标