Genistein solid dispersion: preparation, physical-chemical  characters and anti-oxidant properties

摘要/Abstract

摘要：

The aim of this study was to enhance the applicability of genistein (GEN) and investigate genistein solid dispersion (GEN-SD). The optimal process parameters were determined as follows: anhydrous ethanol volume ratio of 4:1, ultrasonication time of 30 min, rotary evaporation temperature of 50 °C, and a drug-to-carrier mass ratio of 1:7. The results of the dissolution and solubility experiments showed that the dissolution rate and solubility of the optimized solid dispersion were signifi cantly improved compared to pure GEN. Comprehensive characterization of the GEN-SD using X-ray diff raction, differential scanning calorimetry, scanning electron microscopy, and Fourier transform infrared spectroscopy clarified variations in crystalline form, thermal properties, and microscopic morphology. Antioxidant experiments showed that GENSD exhibited antioxidant activity and could effectively scavenge various free radicals. Stability studies demonstrated that GEN-SD was stable at a high temperature of 60 ℃ and a light intensity of 4500 lx.

关键词: Genistein, Solid dispersion, Polyvinylpyrrolidone K30, Antioxidant

Abstract:

Key words: Genistein, Solid dispersion, Polyvinylpyrrolidone K30, Antioxidant

Xiaofei Liu, Yang Liu, Hongyue Wang, Xiangrong Zhang .

Genistein solid dispersion: preparation, physical-chemical characters and anti-oxidant properties

[J]. 多酚, 2025, 7(3): 112-126.

Xiaofei Liu, Yang Liu, Hongyue Wang, Xiangrong Zhang .

Genistein solid dispersion: preparation, physical-chemical characters and anti-oxidant properties

[J]. Journal of Polyphenols, 2025, 7(3): 112-126.

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