多酚杂志

本期目录

2021年, 第3卷, 第1期　刊出日期：2021-12-03 上一期    下一期

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A review: effect and mechanism of plant extracts rich in polyphenols on reducing uric acid activity Shuping Wang, Fuqi Wang, Ruowen Zhang, Xu Zhao 2021 (1):  1-13.  摘要 ( 1026 )   PDF(5761KB) ( 833 )   Abstract Hyperuricemia is a metabolic condition caused by the increase of uric acid level in the body, which can lead to gout, kidney disease, cardiovascular disease, hypertension and diabetes. In recent years, the incidence rate of hyperuricemia has been increasing and gradually becoming younger. Allopurinol and febuxostat are commonly used drugs to reduce the level of uric acid in the body. Although these drugs have good curative eff ect, they can produce adverse reactions. Therefore, it has been the focus of attention to fi nd appropriate treatment and new drugs to reduce serum uric acid level. Natural plants have become the source of new drugs for their multiple biological activities, strong effi cacy and minimal side eff ects. More and more studies have shown that natural plant extracts rich in phenols, fl avonoids and other active components can signifi cantly reduce the level of uric acid, and improve the complications caused by high uric acid. In this paper, hyperuricemia related diseases, functional plants rich in polyphenols with the effect of reducing uric acid and the mechanism of their active components were reviewed. 相关文章 | 计量指标

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New N-acetyl-L-cysteine derivatives synthesized by the degradation of proanthocyanidins as high biological activity antioxidants Yuxuan Wang, Ruifang Bai, Siqi Luo, Meng Huang, Yan Cui 2021 (1):  14-31.  摘要 ( 783 )   PDF(13490KB) ( 141 )   Abstract A novel degradation method was investigated to synthesize highly biologically active flavan-3-ol derivatives in the presence of N-acetyl-L-cysteine (NAC) as a nucleophile under acidic conditions for polymerized proanthocyanidins degradation. The reaction conditions were optimized by the combination of single-factor test and central composite experimental design (CCD). Grape seed proanthocyanidins were reacted with NAC at a ratio of 1 : 3 with 0.3 M methanolic HCl, a temperature of 55 ºC, and a reaction time of 50 mins. M ost of the degradation products were separated and prepared by one-step high-speed countercurrent chromatography (HSCCC) and preparative high-performance liquid chromatography (prep-HPLC). Three monomeric proanthocyanidins and four new N-acetyl-L-cysteine derivatives were isolated from degradation products with total degradation yield of 55.44% and high purity over 95%. Furthermore, the neuroprotective abilities of these compounds to H2O2-treated PC-12 neuroblastoma cells were evaluated. NAC derivatives showed better antioxidant activity than their corresponding underivatized monomers and NAC, indicating that they had a better performance in protecting PC-12 cells from oxidative stress damage. 相关文章 | 计量指标

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Studies on the comparative pharmacokinetic of three phenolic acids of Salvia miltiorrhiza Bunge in normal and hyperlipidemic rats by liquid chromatography-tandem mass spectrometry Xun Gao, Kaishun Bi, Jingqing Mu, Longshan Zhao, Yue Zhang, Shaoyi Guan, Huifen Zhang 2021 (1):  32-41.  摘要 ( 822 )   PDF(2539KB) ( 749 )   Abstract The hydrophilic phenolic acid is the main component of Salvia miltiorrhiza Bunge against cardiovascular diseases. A validated and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was established to simultaneously determinate three phenolic acids (danshensu, protocatechuic acid and rosmarinic acid) in rats to investigate their pharmacokinetic profiles firstly. The values for limit of quantification were in range of 0.25–1.25 μg/L. Meanwhile, the suitable intra-day and inter-day precision as well as extraction recoveries were also obtained. And such an established method was finally successfully applied to compare the pharmacokinetic behaviors of three phenolic acids in normal and hyperlipidemic rats after oral administration of Salvia miltiorrhiza Bunge. The results showed there were significant differences in pharmacokinetic parameters between normal and hyperlipidemic groups. In especial, the plasma level of three phenolic acids in hyperlipidemic groups was signifi cantly higher than normal ones. This comparative pharmacokinetic study provided direct evidence for improving clinical rational use of Salvia miltiorrhiza Bunge. 相关文章 | 计量指标

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Research progress of phenolic compounds and pharmacological effects in Cerasus Yihan Sun, Sheng Dong, Caibin Yang, Yaqi Wang, Guogang Zhang 2021 (1):  42-61.  摘要 ( 823 )   PDF(2338KB) ( 975 )   Abstract The phenolic compounds in Cerasus were complex, mainly including fl avonoids, phenolic acids and lignin, and had antioxidant, anti-infl ammatory, anti-tumor, hypoglycemic and other pharmacological activities. Its fruit contains calcium, sugar, iron, phosphorus, protein, carotene and vitamin C, which has high nutritional value. This paper reviews the research progress of chemical constituents and pharmacological eff ects of Cerasus in recent years, so as to provide reference for its further research. 相关文章 | 计量指标

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Extraction and application of tannin in the medical, food and chemical industries Xindi Zhang, Hongyue Wang, Qianyun Jia, Jiaqing Cao, Xiangrong Zhang 2021 (1):  62-75.  摘要 ( 893 )   PDF(1596KB) ( 2129 )   Abstract Tannins are kinds of polyphenols found in plants, which can be divided into hydrolyzed tannins and condensed tannins according to the structure. They are extracted using solid/liquid, supercritical, pressurized water, and microwaveassisted extraction approaches. Because of the excellent antioxidant and antibacterial properties, tannins are widely used in medicine and food process. Considering the above advantages, the present review focused on various techniques to extract tannins and their application in the medical, food and chemical industries. 相关文章 | 计量指标

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Optimization of ultrasonic-assisted enzymatic extraction of flavonoids from the fruit of Aronia melanocarpa Yan Wang, Ming Song, Wei Xu, Weizhuo Xu 2021 (1):  76-83.  摘要 ( 862 )   PDF(1179KB) ( 776 )   Abstract As a new resource food, Aronia melanocarpa is rich in fl avonoids, which has a broad development prospect. In order to obtain a higher extraction rate of fl avonoids, cellulase was used to extract total fl avonoids from the fruits of Aronia melanocarpa by ultrasonic-assisted enzymatic extraction (UAEE). The extraction process was optimized by single factor experiment and orthogonal experiment. The optimum conditions were as follows: enzymatic hydrolysis time 2.0 h, enzymatic hydrolysis temperature 37 ℃, enzyme content 0.5% (by weight of fruit pulp), ethanol concentration 90%, solid-liquid ratio 1 : 20, enzymatic hydrolysis temperature 37 ℃, enzymatic hydrolysis temperature 37 ℃, enzyme content 0.5% (by weight of fruit pulp), ethanol concentration 90%. Ultrasonic extraction time 1.0h, temperature 45 ℃. Under the above conditions, the extraction yield of fl avonoids reached 1.455 mg/g. Compared with ultrasonic-assisted extraction (UAE), the extraction yield was signifi cantly improved. Therefore, ultrasonic-assisted enzymatic hydrolysis is an eff ective method for the extraction of total fl avonoids from Aronia melanocarpa. 相关文章 | 计量指标